World Journal of Engineering Research and Technology

Kothwala Dr. Devesh Kumar, Patel Hemant and Mansi Desai*

ABSTRACT

Atrial Septal Defect (ASD) is a prevalent congenital cardiac malformation characterized by a persistent patency in the inter-atrial septum, facilitating aberrant left-to-right shunting of blood. If left untreated, ASD may precipitate adverse sequelae such as right ventricular volume overload, atrial arrhythmogenesis, pulmonary arterial hypertension, and eventual cardiac failure. While surgical correction was historically the standard of care, transcatheter closure utilizing septal occluder devices has emerged as a minimally invasive and clinically efficacious intervention. This research articles evaluates the mechanical performance and design optimization of a nitinol-basedseptal defect occluder incorporating polyethylene terephthalate (PET) membrane patches. The device was subjected to in-vitro simulation protocols designed to replicate human atrial morphology and physiological hemodynamic environments. Comprehensive bench-top assessments were performed to quantify key functional parameters, including delivery system compatibility, structural conformability to septal anatomy. Experimental findings revealed that the device exhibited consistent deliverability through conventional catheter-based introducer systems, with excellent conformability to the septal tissue. Furthermore, sealing efficacy across a spectrum of defect diameters was validated, indicating reliable performance under varying anatomical scenarios. Collectively, these results underscore the importance of in-vitro mechanical validation in the preclinical development of ASD occluders, facilitating iterative design refinement and enhancing both safety profiles and therapeutic outcomes prior to clinical deployment.

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